JBS Authors Choice Award

JBS Authors Choice AwardThe paper “Are GPCRs Still a Source of New Targets?” written by Stephen Garland has won the 2016 JBS Authors Choice Award reflecting its popularity among authors (citations) throughout 2015. The paper is open access and can be readily downloaded from the JBS website.

The article discusses the wide range of opportunities that remain for discovery of new drugs at arguably the most successful class of drug targets to date, including under-exploited receptor sub-classes, new chemical diversity, advances in understanding of receptor pharmacology, screening technology and protein X-ray crystallography, as well as the scope for allosteric mechanisms, alternative signalling pathways, the discovery of “biased” ligands and the emergence of GPCR-protein complexes as potential drug targets.